Yes

Miscellaneous Product

Unlabeled uses: Treat SSRI-induced sexual dysfunction; weight loss; impotence; sympathicolytic and mydriatic; may have activity as an aphrodisiac

Renal disease, hypersensitivity to yohimbine

Do not use in pregnancy; do not use in children; not for use in geriatric, psychiatric, or cardio-renal patients with a history of gastric or duodenal ulcer; generally not for use in females. Should not be used in kidney disease or psychiatric disorders; can cause high blood pressure and anxiety, tachycardia, nausea, or vomiting.

Cardiovascular: Tachycardia, hypertension, hypotension (orthostatic), flushing

Central nervous system: Anxiety, mania, hallucinations, irritability, dizziness, psychosis, insomnia, headache, panic attacks

Gastrointestinal: Nausea, vomiting, anorexia, salivation

Neuromuscular & skeletal: Tremors

Miscellaneous: Antidiuretic action, diaphoresis

CYP2D6 and 3A3/4 enzyme substrate; CYP2D6 enzyme inhibitor

Derived from the bark of the yohimbe tree ( Corynanthe yohimbe), this indole alkaloid produces a presynaptic alpha₂-adrenergic blockade. Peripheral autonomic effect is to increase cholinergic and decrease adrenergic activity; yohimbine exerts a stimulating effect on the mood and a mild antidiuretic effect.

Absorption: Oral: 33%

Half-life: 0.6 hour

Adults: Oral:

Orthostatic hypotension: Doses of 12.5 mg/day have been utilized; however, more research is necessary

No information available to require special precautions

No effects or complications reported

Considered unsafe

Tablet, as hydrochloride: 5.4 mg