No

Immune Globulin

Passive immunization against tetanus; tetanus immune globulin is preferred over tetanus antitoxin for treatment of active tetanus; part of the management of an unclean, wound in a person whose history of previous receipt of tetanus toxoid is unknown or who has received less than three doses of tetanus toxoid; elderly may require TIG more often than younger patients with tetanus infection due to declining antibody titers with age

C

Hypersensitivity to tetanus immune globulin, thimerosal, or any immune globulin product or component; patients with IgA deficiency; I.V. administration

Have epinephrine 1:1000 available for anaphylactic reactions; do not administer I.V.

>10%: Local: Pain, tenderness, erythema at injection site

1% to 10%:

Central nervous system: Fever (mild)

Dermatologic: Urticaria, angioedema

Neuromuscular & skeletal: Muscle stiffness

Miscellaneous: Anaphylaxis reaction

<1%: Sensitization to repeated injections

Never administer tetanus toxoid and TIG in same syringe (toxoid will be neutralized); toxoid may be given at a separate site; concomitant administration with Td may decrease its immune response, especially in individuals with low prevaccination antibody titers

Refrigerate

Passive immunity toward tetanus

Absorption: Well absorbed

I.M.:

Children: 4 units/kg; some recommend administering 250 units to small children

Adults: 250 units

Treatment of tetanus:

Children: 500-3000 units; some should infiltrate locally around the wound

Adults: 3000-6000 units

Do not administer I.V.; I.M. use only

No information available to require special precautions

No effects or complications reported

Be aware of adverse reactions

Injection: 250 units/mL