No

Antitoxin

Tetanus prophylaxis or treatment of active tetanus only when tetanus immune globulin (TIG) is not available; tetanus immune globulin (Hyper-Tet®) is the preferred tetanus immunoglobulin for the treatment of active tetanus; may be given concomitantly with tetanus toxoid adsorbed when immediate treatment is required, but active immunization is desirable

D

Patients sensitive to equine-derived preparations

Tetanus antitoxin is not the same as tetanus immune globulin; sensitivity testing should be conducted in all individuals regardless of clinical history; have epinephrine 1:1000 available

greater than or equal to 10%: Skin eruptions, erythema, urticaria, local pain, numbness, arthralgia, serum sickness may develop up to several weeks after injection, anaphylaxis

Refrigerate, do not freeze

Provides passive immunization; solution of concentrated globulins containing antitoxic antibodies obtained from horse serum after immunization against tetanus toxin

Prophylaxis: I.M., S.C.:

Children <30 kg: 1500 units

Children and Adults greater than or equal to 30 kg: 3000-5000 units

Treatment: Children and Adults: Inject 10,000-40,000 units into wound; administer 40,000-100,000 units

All patients should have sensitivity testing prior to starting therapy with tetanus antitoxin

Injection, equine: Not less than 400 units/mL (12.5 mL, 50 mL)