Yes

Antibiotic, Sulfonamide Derivative; Local Anesthetic

Treatment of urinary tract infections and nocardiosis

B/D (at term)

Porphyria; hypersensitivity to any sulfa drug or any component; pregnancy at term; children <2 months of age unless indicated for the treatment of congenital toxoplasmosis; sunscreens containing PABA

>10%:

Central nervous system: Fever, dizziness, headache

Dermatologic: Itching, rash, photosensitivity

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea

1% to 10%:

Dermatologic: Lyell's syndrome, Stevens-Johnson syndrome

Hematologic: Granulocytopenia, leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia

Hepatic: Hepatitis

Decreased effect with PABA or PABA metabolites of drugs (ie, procaine, proparacaine, tetracaine); cyclosporine levels may be decreased

Increased effect/toxicity of oral anticoagulants, oral hypoglycemic agents, hydantoins, uricosuric agents, methotrexate when administered with sulfonamides

Increased toxicity of sulfonamides with diuretics, indomethacin, methenamine, probenecid, and salicylates

Interferes with bacterial growth by inhibiting bacterial folic acid synthesis through competitive antagonism of PABA; phenazopyridine exerts local anesthetic or analgesic action on urinary tract mucosa through an unknown mechanism

Absorption: Sulfisoxazole acetyl is hydrolyzed in the GI tract to sulfisoxazole which is readily absorbed

Serum half-life: 4-7 hours, prolonged with renal impairment

Time to peak serum concentration: Within 2-3 hours

Adults: Oral: 4-6 tablets to start, then 2 tablets 4 times/day for 2 days, then continue with sulfisoxazole only

Should be administered 1 hour before or 2 hours after a meal on an empty stomach

Administer around-the-clock rather than 4 times/day to promote less variation in peak and trough serum levels

Dizziness is common; sulfonamides reported to cause restlessness, irritability, depression, euphoria, disorientation, panic, hallucinations, and delusions

Photosensitivity is common; use caution with concurrent psychotropics; may cause leukopenia; caution with clozapine and carbamazepine

No information available to require special precautions

No effects or complications reported

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to get pregnant. Consult prescriber if breast-feeding.

May cause reddish-orange discoloration of urine; staining of contact lenses has also been reported; drink plenty of fluids; administer on an empty stomach; avoid prolonged exposure to sunlight or wear protective clothing and sunscreen; notify physician if rash, difficulty breathing, severe or persistent fever, or sore throat occurs

Tablet: Sulfisoxazole 500 mg and phenazopyridine 50 mg