Yes

Antibiotic, Sulfonamide Derivative

Treatment of urinary tract infections complicated with pain

B/D (at term)

Porphyria; hypersensitivity to any sulfa drug or any component

Central nervous system: Confusion, depression, hallucinations, ataxia, seizures, fever, kernicterus in neonates

Dermatologic: Rash, erythema multiforme, Stevens-Johnson syndrome, epidermal necrolysis

Gastrointestinal: Nausea, vomiting, glossitis, stomatitis, diarrhea, pseudomembranous colitis

Hematologic: Thrombocytopenia, megaloblastic anemia, granulocytopenia, aplastic anemia, hemolysis (with G-6-PD deficiency)

Hepatic: Serum sickness, hepatitis

Renal & genitourinary: Interstitial nephritis

Warfarin, methotrexate

Oral: 4 tablets to start, then 2 tablets twice daily for up to 2 days, then switch to sulfamethoxazole only

Should be administered 1 hour before or 2 hours after a meal on an empty stomach

May cause confusion, depression, and hallucinations; sulfonamides reported to cause restlessness, irritability, euphoria, disorientation, panic, and delusions

Photosensitivity is common; use caution with concurrent psychotropics; may cause leukopenia; caution with clozapine and carbamazepine

No information available to require special precautions

No effects or complications reported

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to get pregnant. Consult prescriber if breast-feeding.

Urine may be discolored orange-red; when possible, obtain specimens for culture and sensitivity before the first dose; review allergy history

Tablet: Sulfamethoxazole 500 mg and phenazopyridine 100 mg