|
| U.S. Brand
Names |
|
| Sotradecol®
Injection |

|
|
| Generic
Available |
|
|
No |

|
|
| Synonyms |
|
|
Sodium Tetradecyl Sulfate |

|
|
| Pharmacological Index |
|
|
Sclerosing Agent |

|
|
| Use |
|
|
Treatment of small, uncomplicated varicose veins of the lower extremities;
endoscopic sclerotherapy in the management of bleeding esophageal
varices |

|
|
| Pregnancy Risk
Factor |
|
|
C |

|
|
| Contraindications |
|
|
Arterial disease, thrombophlebitis, hypersensitivity to sodium tetradecyl or
any component, valvular or deep vein incompetence, phlebitis, migraines,
cellulitis, acute infections; bedridden patients; patients with uncontrolled
systemic disease such as diabetes, toxic hyperthyroidism, tuberculosis, asthma,
neoplasm, sepsis, blood dyscrasias, and acute respiratory or skin
diseases |

|
|
| Warnings/Precautions |
|
|
Buerger's disease, peripheral arteriosclerosis, avoid extravasation; observe
for hypersensitivity/anaphylactic reaction |

|
|
| Adverse
Reactions |
|
|
Percentage unknown: Headache, urticaria; sloughing and tissue necrosis
following extravasation; nausea, vomiting, mucosal lesions, esophageal
perforation, discoloration at the site of injection, ulceration at the site,
pain at injection site, pulmonary edema, asthma |

|
|
| Drug
Interactions |
|
|
Chemically incompatible with heparin |

|
|
| Stability |
|
|
Store at controlled room temperature in a well-closed container; protect from
light |

|
|
| Mechanism of
Action |
|
|
Acts by irritation of the vein intimal endothelium |

|
|
| Usual Dosage |
|
|
I.V.: Test dose: 0.5 mL given several hours prior to administration of larger
dose; 0.5-2 mL in each vein, maximum: 10 mL per treatment session; 3% solution
reserved for large varices |

|
|
| Administration |
|
|
Inject slowly |

|
|
| Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
|
No information available to require special precautions |

|
|
| Dental Health:
Effects on Dental Treatment |
|
|
No effects or complications reported |

|
|
| Patient
Information |
|
|
Notify physician if chest pain, shortness of breath, or heat, pain, or
tenderness in lower extremities |

|
|
| Nursing
Implications |
|
|
Observe for signs and symptoms of embolism |

|
|
| Dosage Forms |
|
|
Injection, as sulfate: 1% [10 mg/mL] (2 mL); 3% [30 mg/mL] (2
mL) |

|
|
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|