No

Ophthalmic Agent, Viscoelastic

Surgical aid in cataract extraction, intraocular implantation, corneal transplant, glaucoma filtration, and retinal attachment surgery

C

Hypersensitivity to hyaluronate

Do not overfill the anterior chamber; carefully monitor intraocular pressure; risk of hypersensitivity exists

1% to 10%: Ocular: Postoperative inflammatory reactions (iritis, hypopyon), corneal edema, corneal decompensation, transient postoperative increase in IOP

Store in refrigerator (2°C to 8°C); do not freeze

Functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues. Sodium hyaluronate is a polysaccharide which is distributed widely in the extracellular matrix of connective tissue in man. (Vitreous and aqueous humor of the eye, synovial fluid, skin, and umbilical cord.) Sodium hyaluronate forms a viscoelastic solution in water (at physiological pH and ionic strength) which makes it suitable for aqueous and vitreous humor in ophthalmic surgery.

Absorption: Following intravitreous injection, diffusion occurs slowly

Elimination: By way of the Canal of Schlemm

Depends upon procedure (slowly introduce a sufficient quantity into eye)

The drug may become cloudy or form a slight precipitate after administration; clinical significance unknown, but cloudy or precipitated material should be removed by irrigation or aspiration

Intraocular pressure

No information available to require special precautions

No effects or complications reported

Injection, intraocular:

Healon®: 10 mg/mL (0.4 mL, 0.55 mL, 0.85 mL, 2 mL)

Amvisc®: 12 mg/mL (0.5 mL, 0.8 mL)

Healon® GV: 14 mg/mL (0.55 mL, 0.85 mL)

Amvisc® Plus: 16 mg/mL (0.5 mL, 8 mL)

AMO Vitrax®: 30 mg/mL (0.65 mL)

Injection (Hyalgan®): 10 mg/mL (2 mL)