No

Alkalinizing Agent

Treatment of metabolic acidosis; alkalinizing agent in conditions where long-term maintenance of an alkaline urine is desirable

No rating

Severe renal insufficiency, sodium-restricted diet

Conversion to bicarbonate may be impaired in patients with hepatic failure, in shock, or who are severely ill

1% to 10%:

Endocrine & metabolic: Metabolic alkalosis, hyperkalemia

Gastrointestinal: Diarrhea, nausea, vomiting

Symptoms of overdose include hypokalemia, hypernatremia, tetany, seizures

Hypernatremia is resolved through the use of diuretics and free water replacement

Decreased effect/levels of lithium, chlorpropamide, salicylates due to urinary alkalinization

Increased toxicity/levels of amphetamines, ephedrine, pseudoephedrine, flecainide, quinidine, quinine due to urinary alkalinization

Oral:

Adults: 15-30 mL with water after meals and at bedtime

Should be administered after meals to avoid laxative effect

No information available to require special precautions

No effects or complications reported

Take as often as directed, preferably on an empty stomach (1 hour before or 2 hours after meals) and at least 2 hours before or after any other medications. Dilute with 4-6 ounces of chilled water. You may experience diarrhea or nausea and vomiting; if severe, contact prescriber. Report changes in CNS status (eg, irritability, tremors, confusion), swelling of feet or ankles, difficulty breathing, palpitations, abdominal pain, or tarry stools.

May be ordered as modified Shohl's solution; dilute with 30-90 mL of chilled water to enhance taste

Solution, oral:

Oracit®: Sodium citrate 490 mg and citric acid 640 mg per 5 mL

Polycitra®: Sodium citrate 500 mg and citric acid 334 mg with potassium citrate 550 mg per 5 mL