|
| U.S. Brand
Names |
|
| Vexol® Ophthalmic
Suspension |

|
|
| Generic
Available |
|
|
No |

|
|
| Pharmacological Index |
|
|
Corticosteroid, Ophthalmic |

|
|
| Use |
|
|
Treatment of inflammation after ocular surgery and the treatment of anterior
uveitis |

|
|
| Pregnancy Risk
Factor |
|
|
C |

|
|
| Contraindications |
|
|
Fungal, viral, or untreated pus-forming bacterial ocular infections;
hypersensitivity to any component |

|
|
| Warnings/Precautions |
|
|
Prolonged use has been associated with the development of corneal or scleral
perforation and posterior subcapsular cataracts; may mask or enhance the
establishment of acute purulent untreated infections of the eye; effectiveness
and safety have not been established in children |

|
|
| Adverse
Reactions |
|
|
1% to 10%: Ocular: Temporary mild blurred vision
<1%: Stinging, burning eyes, corneal thinning, increased intraocular
pressure, glaucoma, damage to the optic nerve, defects in visual activity,
cataracts, secondary ocular infection |

|
|
| Overdosage/Toxicology |
|
|
Systemic toxicity is unlikely from the ophthalmic
preparation |

|
|
| Mechanism of
Action |
|
|
Decreases inflammation by suppression of migration of polymorphonuclear
leukocytes and reversal of increased capillary permeability |

|
|
| Pharmacodynamics/Kinetics |
|
|
Absorption: Through aqueous humor
Metabolism: Any drug absorbed is metabolized in the liver
Elimination: By the kidneys and feces |

|
|
| Usual Dosage |
|
|
Adults: Ophthalmic: Instill 1 drop in conjunctival sac 2-4 times/day up to
every 4 hours; may use every 1-2 hours during first 1-2
days |

|
|
| Monitoring
Parameters |
|
|
Intraocular pressure and periodic examination of lens (with prolonged
use) |

|
|
| Mental Health: Effects
on Mental Status |
|
|
None reported |

|
|
| Mental Health:
Effects on Psychiatric
Treatment |
|
|
None reported |

|
|
| Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
|
No information available to require special precautions |

|
|
| Dental Health:
Effects on Dental Treatment |
|
|
No effects or complications reported |

|
|
| Patient
Information |
|
|
Shake well before using, do not touch dropper to the eye |

|
|
| Dosage Forms |
|
|
Suspension, ophthalmic: 1% (5 mL, 10
mL) |

|
|
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|