| U.S. Brand Names |
| Riobin® |
 |
| Generic Available |
|
Yes |
|
| Synonyms |
| Lactoflavin; Vitamin B2; Vitamin G |
|
| Pharmacological Index |
|
Vitamin, Water Soluble |
|
| Use |
|
Dental and Medical: Prevent riboflavin deficiency and treat ariboflavinosis |
|
| Pregnancy Risk Factor |
|
A/C (if dose exceeds RDA recommendation) |
|
| Warnings/Precautions |
|
Riboflavin deficiency often occurs in the presence of other B vitamin deficiencies |
|
| Adverse Reactions |
|
Genitourinary: Discoloration of urine (yellow-orange) |
|
| Drug Interactions |
|
Decreased absorption with probenecid |
|
| Mechanism of Action |
|
Component of flavoprotein enzymes that work together, which are necessary for normal tissue respiration; also needed for activation of pyridoxine and conversion of tryptophan to niacin |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Readily via GI tract, however, food increases extent of GI absorption; GI absorption is decreased in patients with hepatitis, cirrhosis, or biliary obstruction Metabolism: Metabolic fate unknown Half-life, biologic: 66-84 minutes Elimination: 9% excreted unchanged in urine |
|
| Usual Dosage |
|
Oral: Children: 2.5-10 mg/day in divided doses Adults: 5-30 mg/day in divided doses Recommended daily allowance: Children: 0.4-1.8 mg Adults: 1.2-1.7 mg |
|
| Test Interactions |
|
Large doses may interfere with urinalysis based on spectrometry; may cause false elevations in fluorometric determinations of catecholamines and urobilinogen |
|
| Mental Health: Effects on Mental Status |
|
None reported |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Take with food. Large doses may cause bright yellow or orange urine. |
|
| Nursing Implications |
|
Monitor CBC and reticulocyte counts (if anemic when treating deficiency) |
|
| Dosage Forms |
|
Tablet: 25 mg, 50 mg, 100 mg |
|
|
Copyright © 2007 Drugs Area |
