No

Anthelmintic

Treatment of pinworms ( Enterobius vermicularis), whipworms ( Trichuris trichiura), roundworms ( Ascaris lumbricoides), and hookworms ( Ancylostoma duodenale)

C

Known hypersensitivity to pyrantel pamoate

Use with caution in patients with liver impairment, anemia, malnutrition, or pregnancy. Since pinworm infections are easily spread to others, treat all family members in close contact with the patient.

1% to 10%: Gastrointestinal: Anorexia, nausea, vomiting, abdominal cramps, diarrhea

<1%: Dizziness, drowsiness, insomnia, headache, rash, elevated liver enzymes, tenesmus, weakness

Symptoms of overdose include anorexia, nausea, vomiting, cramps, diarrhea, ataxia

Treatment is supportive following GI decontamination

Decreased effect with piperazine

Protect from light

Causes the release of acetylcholine and inhibits cholinesterase; acts as a depolarizing neuromuscular blocker, paralyzing the helminths

Absorption: Oral: Poor

Metabolism: Undergoes partial hepatic metabolism

Time to peak serum concentration: Within 1-3 hours

Elimination: In feces (50% as unchanged drug) and urine (7% as unchanged drug)

Children and Adults (purgation is not required prior to use): Oral:

Hookworm: 11 mg/kg administered once daily for 3 days

May be mixed with milk or fruit juice

Stool for presence of eggs, worms, and occult blood, serum AST and ALT

May cause dizziness, drowsiness, or insomnia

None reported

No information available to require special precautions

No effects or complications reported

May mix drug with milk or fruit juice; strict hygiene is essential to prevent reinfection

Shake well before pouring to assure accurate dosage; protect from light

Capsule: 180 mg

Liquid: 50 mg/mL (30 mL); 144 mg/mL (30 mL)

Suspension, oral (caramel-currant flavor): 50 mg/mL (60 mL)

"Drugs for Parasitic Infections," Med Lett Drugs Ther, 1998, 40(1017):1-12.