No

Diagnostic Agent, Thyroid Function

Adjunct in the diagnostic assessment of thyroid function, and an adjunct to other diagnostic procedures in patients with pituitary or hypothalamic dysfunction; also causes release of prolactin from the pituitary and is used to detect defective control of prolactin secretion

C

Hypersensitivity to protirelin additives

>10%:

Central nervous system: Headache, lightheadedness

Dermatologic: Flushing of face

Gastrointestinal: Nausea, xerostomia

Genitourinary: Urge to urinate

1% to 10%:

Central nervous system: Anxiety

Endocrine & metabolic: Breast enlargement and leaking in lactating women

Gastrointestinal: Bad taste in mouth, abdominal discomfort

Neuromuscular & skeletal: Tingling

Miscellaneous: Diaphoresis

Decreased effect: Aspirin, levodopa, thyroid hormones, adrenocorticoid drugs

Increase release of thyroid stimulating hormone from the anterior pituitary

Peak TSH levels: 20-30 minutes

Duration: TSH returns to baseline after ~3 hours

Serum half-life, mean plasma: 5 minutes

I.V.:

Children 6-16 years: 7 mcg/kg to a maximum dose of 500 mcg

Adults: 500 mcg (range 200-500 mcg)

Administer I.V. bolus over 15-30 seconds with patient remaining in supine position; monitor blood pressure frequently during and 15 minutes after administration

Dizziness is common; may cause anxiety

None reported

No information available to require special precautions

>10% of patients experience dry mouth

Keep patient supine during drug administration; administer undiluted direct I.V. over 15-30 seconds with the patient remaining supine for an additional 15 minutes

Monitor blood pressure, prolactin, TSH, T₄ and T₃

Injection: 500 mcg/mL (1 mL)