| Generic Available |
|
No |
 |
| Synonyms |
| Biphenabid |
|
| Pharmacological Index |
|
Antilipemic Agent (Miscellaneous) |
|
| Use |
|
Adjunct to dietary therapy to decrease elevated serum total and LDL cholesterol concentrations in primary hypercholesterolemia |
|
| Pregnancy Risk Factor |
|
B |
|
| Contraindications |
|
Ventricular arrhythmias; hypersensitivity to probucol or any component |
|
| Adverse Reactions |
|
>10%: Cardiovascular: Q-T prolongation, serious arrhythmias Gastrointestinal: Bloating, diarrhea, stomach pain, nausea, vomiting 1% to 10%: Central nervous system: Dizziness, headache, numbness of extremities |
|
| Drug Interactions |
|
Increased toxicity: Drugs that prolong the Q-T interval (eg, tricyclic antidepressants, some antiarrhythmic agents, phenothiazines) or with drugs that affect the atrial rate (eg, beta-adrenergic blocking agents) or that can cause A-V block (eg, digoxin) |
|
| Mechanism of Action |
|
Increases the fecal loss of bile acid-bound low density lipoprotein cholesterol, decreases the synthesis of cholesterol and inhibits enteral cholesterol absorption |
|
| Usual Dosage |
|
Oral: <27 kg: 250 mg twice daily with meals >27 kg: 500 mg twice daily with meals Adults: 500 mg twice daily administered with the morning and evening meals |
|
| Mental Health: Effects on Mental Status |
|
May cause dizziness |
|
| Mental Health: Effects on Psychiatric Treatment |
|
Concurrent use with phenothiazines, TCAs, or beta-blockers may produce AV block |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Take with meals; notify physician if diarrhea, abdominal pain, nausea, or vomiting becomes severe or persist |
|
| Dosage Forms |
|
Tablet: 250 mg, 500 mg |
|
|
Copyright © 2007 Drugs Area |
