| U.S. Brand Names |
| Anusol® Ointment [OTC]; Fleet® Pain Relief [OTC]; Itch-X®[OTC]; Phicon®[OTC]; PrameGel®[OTC]; Prax®[OTC]; ProctoFoam® NS [OTC]; Tronolane®[OTC] |
 |
| Generic Available |
|
No |
|
| Synonyms |
| Pramoxine Hydrochloride |
|
| Pharmacological Index |
|
Local Anesthetic |
|
| Use |
|
Temporary relief of pain and itching associated with anogenital pruritus or irritation; dermatosis, minor burns, or hemorrhoids |
|
| Pregnancy Risk Factor |
|
C |
|
| Adverse Reactions |
|
1% to 10%: Dermatologic: Angioedema Local: Contact dermatitis, burning, stinging <1%: Cardiovascular: Edema Dermatologic: Urticaria Genitourinary: Urethritis Hematologic: Methemoglobinemia in infants Local: Tenderness |
|
| Drug Interactions |
|
No data reported |
|
| Mechanism of Action |
|
Pramoxine, like other anesthetics, decreases the neuronal membrane's permeability to sodium ions; both initiation and conduction of nerve impulses are blocked, thus depolarization of the neuron is inhibited |
|
| Pharmacodynamics/Kinetics |
|
Onset of therapeutic effect: Within 2-5 minutes Peak effect: 3-5 minutes Duration: May last for several days |
|
| Usual Dosage |
|
Adults: Topical: Apply as directed, usually every 3-4 hours to affected area (maximum adult dose: 200 mg) |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Discontinue if rash appears or if condition worsens or does not improve in 3-4 days |
|
| Nursing Implications |
|
Apply sparingly, use the minimal effective dose |
|
| Dosage Forms |
|
Pramoxine hydrochloride: Cream: Prax®: 1% (30 g, 113.4 g, 454 g) Tronolane®: 1% (30 g, 60 g) Tronothane® HCl: 1% (28.4 g) Gel, topical: Itch-X®: 1% (35.4 g) PrameGel®: 1% (118 g) Lotion (Prax®): 1% (15 mL, 120 mL, 240 mL) Ointment (Anusol®): 1% (30 g) Pads (Fleet® Pain Relief): 1% (100s) Spray (Itch-X®): 1% (60 mL) |
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