| U.S. Brand Names |
| ACU-dyne®[OTC]; Aerodine®[OTC]; Betadine®[OTC]; Betadine® 5% Sterile Ophthalmic Prep Solution; Betagan®[OTC]; Biodine [OTC]; Efodine®[OTC]; Iodex®[OTC]; Iodex-p®[OTC]; Mallisol®[OTC]; Massengill® Medicated Douche w/Cepticin [OTC]; Minidyne®[OTC]; Operand®[OTC]; Polydine®[OTC]; Summer's Eve® Medicated Douche [OTC]; Yeast-Gard® Medicated Douche |
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| Generic Available |
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Yes |
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| Pharmacological Index |
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Antibiotic, Topical; Topical Skin Product |
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| Use |
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External antiseptic with broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts |
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| Pregnancy Risk Factor |
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D |
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| Contraindications |
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Hypersensitivity to iodine |
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| Warnings/Precautions |
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Highly toxic if ingested; sodium thiosulfate is the most effective chemical antidote; avoid contact with eyes |
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| Adverse Reactions |
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1% to 10%: Dermatologic: Rash, pruritus Local: Local edema <1%: Systemic absorption in extensive burns causing iododerma, metabolic acidosis, and renal impairment |
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| Drug Interactions |
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No data reported |
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| Mechanism of Action |
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Povidone-iodine is known to be a powerful broad spectrum germicidal agent effective against a wide range of bacteria, viruses, fungi, protozoa, and spores. |
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| Pharmacodynamics/Kinetics |
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Absorption: In normal individuals, topical application results in very little systemic absorption; with vaginal administration, however, absorption is rapid and serum concentrations of total iodine and inorganic iodide are increased significantly |
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| Usual Dosage |
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Shampoo: Apply 2 teaspoons to hair and scalp, lather and rinse; repeat application 2 times/week until improvement is noted, then shampoo weekly Topical: Apply as needed for treatment and prevention of susceptible microbial infections |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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Do not swallow; avoid contact with eyes |
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| Nursing Implications |
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Avoid contact with eyes |
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| Dosage Forms |
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Aerosol: 5% (88.7 mL, 90 mL) Antiseptic gauze pads: 10% (3" x 9") Cleanser: Skin: 7.5% (30 mL, 118 mL) Skin, foam: 7.5% (170 g) Topical: 60 mL, 240 mL Concentrate, whirlpool: 3,840 mL Cream: 5% (14 g) Douche (10%): 0.5 oz/packet (6 packets/box), 240 mL Foam, topical (10%): 250 g Gel: Lubricating: 5% (5 g) Vaginal (10%): 18 g, 90 g Liquid: 473 mL Mouthwash (0.5%): 177 mL Ointment, topical: 10% (0.94 g, 3.8 g, 28 g, 30 g, 454 g); 1 g, 1.2 g, 2.7 g packets Perineal wash concentrate: 1% (240 mL); 10% (236 mL) Scrub, surgical: 7.5% (15 mL, 473 mL, 946 mL) Shampoo: 7.5% (118 mL) Solution: Ophthalmic sterile prep: 5% (50 mL) Prep: 30 mL, 60 mL, 240 mL, 473 mL, 1000 mL, 4000 mL Swab aid: 1% Swabsticks: 4" Topical: 10% (15 mL, 30 mL, 120 mL, 237 mL, 473 mL, 480 mL, 1000 mL, 4000 mL) Suppositories, vaginal: 10% |
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| References |
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Apt L, Isenberg SJ, Yoshimori R, et al, "The Effect of Povidone-Iodine Solution at the Conclusion of Ophthalmic Surgery," Am J Ophthalmol, 1995, 119(6):701-5. Dela Cruz F, Brown DH, Leikin JB, et al, "Iodine Absorption After Topical Administration," West J Med, 1987, 146(1):43-5. Klein I and Levey GS, "Iodide Excess and Thyroid Function," Ann Intern Med, 1983, 98(3):406-7. |
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