Yes

Electrolyte Supplement, Oral

Treatment of conditions associated with excessive renal phosphate loss or inadequate GI absorption of phosphate; to acidify the urine to lower calcium concentrations; to increase the antibacterial activity of methenamine; reduce odor and rash caused by ammonia in urine

C

Addison's disease, hyperkalemia, hyperphosphatemia, infected urolithiasis or struvite stone formation, patients with severely impaired renal function

Use with caution in patients with renal disease, hyperkalemia, cardiac disease and metabolic alkalosis

>10%: Gastrointestinal: Diarrhea, nausea, stomach pain, flatulence, vomiting

1% to 10%:

Cardiovascular: Bradycardia

Endocrine & metabolic: Hyperkalemia

Neuromuscular & skeletal: Weakness

Respiratory: Dyspnea

<1%: Arrhythmia, chest pain, edema, mental confusion, tetany (with large doses of phosphate), alkalosis, weight gain, throat pain, decreased urine output, phlebitis, paresthesias, paralysis, pain/weakness of extremities, bone pain, arthralgia, acute renal failure, shortness of breath, thirst

Symptoms of overdose include muscle weakness, paralysis, peaked T waves, flattened P waves, prolongation of QRS complex, ventricular arrhythmias, tetany, calcium phosphate precipitation

Removal of potassium can be accomplished by various means; removal through the GI tract with Kayexalate® administration; by way of the kidney through diuresis, mineralocorticoid administration or increased sodium intake; by hemodialysis or peritoneal dialysis; or by shifting potassium back into the cells by insulin and glucose infusion; calcium chloride reverses cardiac effects.

Decreased effect/levels with aluminum and magnesium-containing antacids or sucralfate which can act as phosphate binders

Increased effect/levels with potassium-sparing diuretics or ACE inhibitors; salicylates

All dosage forms to be mixed in 6-8 oz of water prior to administration

Adults: 1-2 capsules (250-500 mg phosphorus/8-16 mmol) 4 times/day after meals and at bedtime

Should be administered after meals

Serum potassium, sodium, calcium, phosphate, EKG

No information available to require special precautions

No effects or complications reported

Do not swallow, open capsule and dissolve in 6-8 oz of water; powder packets are to be mixed in 6-8 oz of water; tablets should be crushed and mixed in 6-8 oz of water

Tablets may be crushed and stirred vigorously to speed dissolution

See table in Potassium Phosphate monograph