GoLYTELY®; NuLytely®; OCL®|
Electrolyte Lavage Solution|
Cathartic; Laxative, Bowel Evacuant
Bowel cleansing prior to GI examination or following toxic
Gastrointestinal obstruction, gastric retention, bowel perforation, toxic
Safety and efficacy not established in children; do not add flavorings as
additional ingredients before use; observe unconscious or semiconscious patients
with impaired gag reflex or those who are otherwise prone to regurgitation or
aspiration during administration; use with caution in ulcerative colitis,
caution against the use of hot loop polypectomy
>10%: Gastrointestinal: Nausea, abdominal fullness, bloating
1% to 10%: Gastrointestinal: Abdominal cramps, vomiting, anal irritation
Oral medications should not be administered within 1 hour of start of
Use within 48 hours of preparation; refrigerate reconstituted solution; tap
water may be used for preparation of the solution; shake container vigorously
several times to ensure dissolution of powder
Induces catharsis by strong electrolyte and osmotic
Onset of effect: Oral: Within 1-2 hours
The recommended dose for adults is 4 L of solution prior to gastrointestinal
examination, as ingestion of this dose produces a satisfactory preparation in
>95% of patients. Ideally the patient should fast for approximately 3-4 hours
prior to administration, but in no case should solid food be given for at least
2 hours before the solution is given. The solution is usually administered
orally, but may be given via nasogastric tube to patients who are unwilling or
unable to drink the solution.
Oral: At a rate of 240 mL (8 oz) every 10 minutes, until 4 liters are
consumed or the rectal effluent is clear; rapid drinking of each portion is
preferred to drinking small amounts continuously
Nasogastric tube: At a rate of 20-30 mL/minute (1.2-1.8 L/hour); the first
bowel movement should occur approximately 1 hour after the start of
Ideally the patient should fast for approximately 3-4 hours prior to
administration, but in no case should solid food be given for at least 2 hours
before the solution is given
Electrolytes, serum glucose, BUN, urine osmolality
|Dental Health: Local
No information available to require special precautions
Effects on Dental Treatment|
No effects or complications reported
Chilled solution is often more palatable. Produces a watery stool which
cleanses the bowel before examination. Prepare solution according to
instructions on the bottle. For best results, no solid food should be consumed
during the 3- to 4-hour period before drinking solution, but in no case should
solid foods be eaten within 2 hours of taking. Drink 240 mL every 10 minutes.
Rapid drinking of each portion is better than drinking small amounts
continuously. The first bowel movement should occur approximately 1 hour after
the start of administration. May experience some abdominal bloating and
distention before bowel starts to move. If severe discomfort or distention
occurs, stop drinking temporarily or drink each portion at longer intervals
until these symptoms disappear. Continue drinking until the watery stool is
clear and free of solid matter. This usually requires at least 3 L. It is best
to drink all of the solutions. Discard any unused portion.
Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend
to be pregnant. Consult prescriber if breast-feeding.
Rapid drinking of each portion is preferred over small amounts continuously;
first bowel movement should occur in 1 hour; chilled solution often more
palatable; do not add flavorings as additional ingredients before
Powder, for oral solution: PEG 3350 236 g, sodium sulfate 22.74 g, sodium
bicarbonate 6.74 g, sodium chloride 5.86 g and potassium chloride 2.97 g (2000
mL, 4000 mL, 4800 mL, 6000 mL)
Harris CR and Kingston R,
"Gastrointestinal Decontamination, Which Method Is Best?" Postgrad Med,
1992, 92(2):116-22, 125, 128.
Olsen KM, Gurley BJ, Davis GA, et al,
"Comparison of Fluid Volumes With Whole Bowel Irrigation in a Simulated Overdose of Ibuprofen,"
Ann Pharmacother, 1995, 29(3):246-50.
Porter RS and Baker EB, "Drug Clearance by Diarrhea Induction," Am J Emerg
Med, 1985, 3(3):182-6.
Scharman EJ, Lembersky R, and Krenzelok EP,
"Efficiency of Whole Bowel Irrigation With and Without Metoclopramide Pretreatment,"
Am J Emerg Med, 1994, 12(3):302-5.
Sondheimer JM, Sokol RJ, Taylor SF, et al,
"Safety, Efficacy and Tolerance of Intestinal Lavage in Pediatric Patients Undergoing Diagnostic Colonoscopy,"
J Pediatr, 1991, 119(1):148-52.
Tuggle DW, Hoelzer DJ, Tunell WP, et al,
"The Safety and Cost-Effectiveness of Polyethylene Glycol Electrolyte Solution Bowel: Preparation in Infants and Children,"
J Pediatr Surg, 1987, 22(6):513-5.
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