No

Contraceptive

Prevention of pregnancy; progestin only products have higher risk of failure in contraceptive use

X

Known hypersensitivity to norgestrel; thromboembolic disorders, severe hepatic disease, breast cancer, undiagnosed vaginal bleeding, pregnancy

Discontinue if sudden loss of vision or if diplopia or proptosis occur; use with caution in patients with a history of mental depression; use of any progestin during the first 4 months of pregnancy is not recommended

>10%:

Cardiovascular: Edema

Endocrine & metabolic: Breakthrough bleeding, spotting, changes in menstrual flow, amenorrhea

Gastrointestinal: Anorexia

Neuromuscular & skeletal: Weakness

1% to 10%:

Cardiovascular: Embolism, central thrombosis

Central nervous system: Mental depression, fever, insomnia

Dermatologic: Melasma or chloasma, allergic rash with or without pruritus

Endocrine & metabolic: Changes in cervical erosion and secretions, increased breast tenderness

Gastrointestinal: Weight gain or loss

Hepatic: Cholestatic jaundice

Local: Thrombophlebitis

Toxicity is unlikely following single exposures of excessive doses

Supportive treatment is adequate in most cases

Decreased effect: Aminoglutethimide may decrease effects by increasing hepatic metabolism

Inhibits secretion of pituitary gonadotropin (LH) which prevents follicular maturation and ovulation

Absorption: Oral: Readily absorbed

Protein binding: >90%

Metabolism: Primarily hepatic

Half-life: ~20 hours

Administer daily, starting the first day of menstruation, take 1 tablet at the same time each day, every day of the year. If one dose is missed, take as soon as remembered, then next tablet at regular time; if two doses are missed, take 1 tablet and discard the other, then take daily at usual time; if three doses are missed, use an additional form of birth control until menses or pregnancy is ruled out.

Should be administered with food at same time each day

Thyroid function tests, metyrapone test, liver function tests

May cause insomnia or depression

None reported

No information available to require special precautions

Until we know more about the mechanism of interaction, caution is required in prescribing antibiotics to female dental patients taking progestin-only oral contraceptives

Take this medicine only as directed; do not take more of it and do not take it for a longer period of time; if you suspect you may have become pregnant, stop taking this medicine; report any loss of vision or vision changes immediately; avoid excessive exposure to sunlight

Patients should receive a copy of the patient labeling

Tablet: 0.075 mg