Yes

Antibiotic/Corticosteroid, Ophthalmic; Antibiotic/Corticosteroid, Otic; Topical Skin Product

Steroid-responsive inflammatory condition for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists

C

>10%: Miscellaneous: Hypersensitivity

1% to 10%:

Dermatologic: Contact dermatitis, erythema, rash, urticaria

Genitourinary: Bladder irritation

Local: Burning, itching, swelling, pain, stinging

Neuromuscular & skeletal: Neuromuscular blockade

Ocular: Increased intraocular pressure, glaucoma, cataracts, conjunctival erythema

Otic: Ototoxicity

Renal: Nephrotoxicity

Miscellaneous: Sensitization to neomycin, secondary infections

No data reported

Refer to individual monographs for neomycin, Polymyxin B, and Hydrocortisone

Duration of use should be limited to 10 days unless otherwise directed by the physician

Otic:

Children: Instill 3 drops into affected ear 3-4 times/day

Adults: Instill 4 drops 3-4 times/day; otic suspension is the preferred otic preparation

Children and Adults:

Ophthalmic: Drops: Instill 1-2 drops 2-4 times/day, or more frequently as required for severe infections; in acute infections, instill 1-2 drops every 15-30 minutes gradually reducing the frequency of administration as the infection is controlled

Topical: Apply a thin layer 1-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Shake suspension well before using. Otic solution should not be used when the integrity of the tympanic membrane is in question.

No information available to require special precautions

No effects or complications reported

Otic: Hold container in hand to warm; if drops are in suspension form, shake well for approximately 10 seconds, lie on your side with affected ear up; for adults hold the ear lobe up and back, for children hold the ear lobe down and back; instill drops in ear without inserting dropper into ear; maintain tilted ear for 2 minutes

Ophthalmic: May cause sensitivity to bright light; may cause temporary blurring of vision or stinging following administration, but discontinue product and see physician if problems persist or increase; to use, tilt head back and place medication in conjunctival sac and close eyes; apply light pressure on lacrimal sac for 1 minute

Cream: Discontinue product if irritation persists or increases

Otic suspension is the preferred otic preparation; otic suspension can be used for the treatment of infections of mastoidectomy and fenestration cavities caused by susceptible organisms; otic solution is used only for superficial infections of the external auditory canal (ie, swimmer's ear)

Cream, topical: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and hydrocortisone 10 mg per mL (7.5 g)

Solution, otic: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and hydrocortisone 10 mg per mL (10 mL)

Suspension:

Ophthalmic: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and hydrocortisone 10 mg per mL (7.5 mL)

Otic: Neomycin sulfate 5 mg, polymyxin B sulfate 10,000 units, and hydrocortisone 10 mg per mL (10 mL)