|
| U.S. Brand
Names |
|
| AK-Trol®; Dexacidin®;
Dexasporin®; Maxitrol® |

|
|
| Generic
Available |
|
|
Yes |

|
|
| Synonyms |
|
|
dexamethasone, neomycin, and polymyxin b; polymyxin b, neomycin, and
dexamethasone |

|
|
| Pharmacological Index |
|
|
Antibiotic/Corticosteroid, Ophthalmic |

|
|
| Use |
|
|
Steroid-responsive inflammatory ocular conditions in which a corticosteroid
is indicated and where bacterial infection or a risk of bacterial infection
exists |

|
|
| Pregnancy Risk
Factor |
|
|
C |

|
|
| Adverse
Reactions |
|
|
1% to 10%:
Ocular: Cutaneous sensitization, eye pain, development of glaucoma, cataract,
increased intraocular pressure, optic nerve damage |

|
|
| Drug
Interactions |
|
|
No data reported |

|
|
| Mechanism of
Action |
|
|
Refer to individual monographs |

|
|
| Pharmacodynamics/Kinetics |
|
|
Refer to individual monographs |

|
|
| Usual Dosage |
|
|
Children and Adults: Ophthalmic:
Solution: Instill 1-2 drops into affected eye(s) every 3-4 hours; in severe
disease, drops may be used hourly and tapered to discontinuation
|

|
|
| Administration |
|
|
Tilt head back, place medication in conjunctival sac and close
eyes |

|
|
| Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
|
No information available to require special precautions |

|
|
| Dental Health:
Effects on Dental Treatment |
|
|
No effects or complications reported |

|
|
| Patient
Information |
|
|
Notify physician if condition worsens or does not improve in 3-4
days |

|
|
| Nursing
Implications |
|
|
Shake well before using
Monitor intraocular pressure with use >10 days |

|
|
| Dosage Forms |
|
|
Ophthalmic:
Suspension: Neomycin sulfate 3.5 mg, polymyxin B sulfate 10,000 units and
dexamethasone 0.1% per mL (5 mL, 10 mL) |

|
|
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|