No

Skeletal Muscle Relaxant

Relief of discomfort associated with acute, painful musculoskeletal conditions

C

Impaired hepatic or renal function, known hypersensitivity to metaxalone, history of drug-induced hemolytic anemias or other anemias

Use with caution in patients with impaired hepatic function

>10%:

Gastrointestinal: Nausea, vomiting, stomach cramps

Central nervous system: Paradoxical stimulation, headache, drowsiness, dizziness

<1%:

Dermatologic: Allergic dermatitis

Hematologic: Leukopenia, hemolytic anemia

Hepatic: Hepatotoxicity

Miscellaneous: Anaphylaxis

Signs and symptoms: No major toxicities have been reported

Increased effect of alcohol, CNS depressants

Does not have a direct effect on skeletal muscle; most of its therapeutic effect comes from actions on the central nervous system

Onset of action: ~1 hour

Duration: ~4-6 hours

Half-life: 2-3 hours

Elimination: In urine as metabolites

Children >12 years and Adults: Oral: 800 mg 3-4 times/day

False-positive Benedict's test

Drowsiness and dizziness are common; may cause paradoxical stimulation

May cause leukopenia; use caution with clozapine and carbamazepine; concurrent use with psychotropics may produce additive sedation

No information available to require special precautions

No effects or complications reported

Avoid alcohol and other CNS depressants; may cause drowsiness, impairment of judgment, or coordination; notify physician of dark urine, pale stools, yellowing of eyes, severe nausea, vomiting, or abdominal pain

Raise bed rails, institute safety measures, assist with ambulation

Tablet: 400 mg