Yes

Laxative, Saline; Magnesium Salt

Evacuation of bowel prior to certain surgical and diagnostic procedures or overdose situations

B

Renal failure, appendicitis, abdominal pain, intestinal impaction, obstruction or perforation, diabetes mellitus, complications in gastrointestinal tract, patients with colostomy, ileostomy, ulcerative colitis or diverticulitis

Use with caution in patients with impaired renal function, especially if Cl_cr <30 mL/minute (accumulation of magnesium which may lead to magnesium intoxication); use with caution in digitalized patients (may alter cardiac conduction leading to heart block); use with caution in patients with lithium administration; use with caution with neuromuscular blocking agents, CNS depressants

1% to 10%:

Endocrine & metabolic: Hypermagnesemia

Gastrointestinal: Abdominal cramps, diarrhea, gas formation

Respiratory: Respiratory depression

Serious, potentially life-threatening electrolyte disturbances may occur with long-term use or overdosage due to diarrhea; hypermagnesemia may occur. CNS depression, confusion, hypotension, muscle weakness, blockage of peripheral neuromuscular transmission.

Serum level >4 mEq/L (4.8 mg/dL): Deep tendon reflexes may be depressed

Serum level greater than or equal to 10 mEq/L (12 mg/dL): Deep tendon reflexes may disappear, respiratory paralysis may occur, heart block may occur

I.V. calcium (5-10 mEq) will reverse respiratory depression or heart block; in extreme cases, peritoneal dialysis or hemodialysis may be required.

Serum level >12 mEq/L may be fatal, serum level greater than or equal to 10 mEq/L may cause complete heart block

Promotes bowel evacuation by causing osmotic retention of fluid which distends the colon with increased peristaltic activity

Absorption: Oral: 15% to 30%

Elimination: Renal

Cathartic: Oral:

<6 years: 0.5 mL/kg up to a maximum of 200 mL repeated every 4-6 hours until stools are clear

6-12 years: 100-150 mL

Adults greater than or equal to 12 years: 1/2 to 1 full bottle (120-300 mL)

Serum magnesium:

Adults: 2.2-2.8 mg/dL ~1.8-2.3 mEq/L

magnesium; protein, calcium (S), potassium (S)

No information available to require special precautions

Magnesium products may prevent gastrointestinal absorption of tetracyclines by forming a large ionized chelated molecule with the tetracyclines in the stomach. Tetracyclines should be given at least 1 hour before magnesium.

Take with a glass of water, fruit juice, or citrus flavored carbonated beverage to improve taste, chill before using; report severe abdominal pain to physician

To increase palatability, manufacturer suggests chilling the solution prior to administration

Solution, oral: 300 mL

Chernow B, Smith J, Rainey TG, et al, "Hypomagnesemia: Implications for the Critical Care Specialist," Crit Care Med, 1982, 10(3):193-6.

Gams JG, "Clinical Significance of Magnesium: A Review," Drug Intell Clin Pharm, 1987, 21(3):240-6.

Vuignier BI, Oderda GM, Gorman RL, et al, "Effects of Magnesium Citrate and Clidinium Bromide on the Excretion of Activated Charcoal in Normal Subjects," DICP, 1989, 23(1):26-9.