No

Antidiuretic Hormone Analog

Controls or prevents signs and complications of neurogenic diabetes insipidus

C

Known hypersensitivity to lypressin

Use with caution in patients with coronary artery disease

1% to 10%:

Cardiovascular: Chest tightness

Central nervous system: Dizziness, headache

Endocrine & metabolic: Water intoxication

Gastrointestinal: Abdominal cramping, increased bowel movements

Local: Irritation or burning

Respiratory: Coughing, dyspnea, rhinorrhea, nasal congestion

<1%: Inadvertent inhalation

Symptoms of overdose include drowsiness, headache, confusion, weight gain, hypertension; systemic toxicity is unlikely to occur from the nasal spray

Increased effect: Chlorpropamide, clofibrate, carbamazepine prolongation of antidiuretic effects

Increases cyclic adenosine monophosphate (cAMP) which increases water permeability at the renal tubule resulting in decreased urine volume and increased osmolality; causes peristalsis by directly stimulating the smooth muscle in the GI tract

Onset of antidiuretic effect: Intranasal spray: Within 0.5-2 hours

Duration: 3-8 hours

Metabolism: In the liver and kidneys

Half-life: 15-20 minutes

Elimination: Urinary excretion

Children and Adults: Instill 1-2 sprays into one or both nostrils whenever frequency of urination increases or significant thirst develops; usual dosage is 1-2 sprays 4 times/day; range: 1 spray/day at bedtime to 10 sprays each nostril every 3-4 hours

May cause dizziness

Carbamazepine may produce prolongation of antidiuretic effects

No information available to require special precautions

No effects or complications reported

To control nocturia, an additional dose may be given at bedtime. Notify prescriber if drowsiness, fatigue, headache, shortness of breath, abdominal cramps, or severe nasal irritation occurs. Pregnancy precautions: Inform prescriber if you are or intend to be pregnant.

Approximately 2 USP posterior pituitary pressor units per spray

Spray: 0.185 mg/mL (equivalent to 50 USP posterior pituitary units/mL) (8 mL)