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| U.S. Brand Names |
| Anatuss® DM [OTC]; Dimacol® Caplets [OTC]; Rhinosyn-X® Liquid [OTC]; Ru-Tuss® Expectorant [OTC]; Sudafed® Cold & Cough Liquid Caps [OTC] |
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| Generic Available |
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Yes |
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| Synonyms |
| Dextromethorphan, Guaifenesin, and Pseudoephedrine; Pseudoephedrine, Dextromethorphan, and Guaifenesin |
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| Pharmacological Index |
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Antitussive/Decongestant/Expectorant |
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| Use |
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Temporarily relieves nasal congestion and controls cough due to minor throat and bronchial irritation; helps loosen phlegm and thin bronchial secretions to make coughs more productive |
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| Warnings/Precautions |
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Research on chicken embryos exposed to concentrations of dextromethorphan relative to those typically taken by humans has shown to cause birth defects and fetal death; more study is needed, but it is suggested that pregnant women should be advised not to use dextromethorphan-containing medications |
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| Adverse Reactions |
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See individual agents |
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| Drug Interactions |
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See individual agents |
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| Mechanism of Action |
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See individual agents |
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| Usual Dosage |
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Adults: Oral: 2 capsules (caplets) or 10 mL every 4 hours |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response |
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| Dental Health: Effects on Dental Treatment |
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Guaifenesin: No effects or complications reported Pseudoephedrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution Dextromethorphan: No effects or complications reported |
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| Dosage Forms |
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Caplets (Dimacol®): Guaifenesin 100 mg, pseudoephedrine hydrochloride 30 mg, and dextromethorphan hydrobromide 10 mg Capsule (Sudafed® Cold & Cough Liquid Caps): Guaifenesin 100 mg, pseudoephedrine hydrochloride 30 mg, and dextromethorphan hydrobromide 10 mg Liquid (Anatuss® DM, Novahistine® DMX Liquid, Rhinosyn-X® Liquid, Ru-Tuss® Expectorant): Guaifenesin 100 mg, pseudoephedrine hydrochloride 30 mg, and dextromethorphan hydrobromide 10 mg per 5 mL |
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