| U.S. Brand Names |
| Amidate® Injection |
 |
| Generic Available |
|
No |
|
| Pharmacological Index |
|
General Anesthetic |
|
| Use |
|
Induction of general anesthesia |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Known hypersensitivity to etomidate |
|
| Warnings/Precautions |
|
Consider exogenous corticosteroid replacement in patients undergoing severe stress |
|
| Adverse Reactions |
|
>10%: Gastrointestinal: Nausea, vomiting Local: Pain at injection site Neuromuscular & skeletal: Transient skeletal movements Ocular: Uncontrolled eye movements 1% to 10%: Hiccups <1%: Hypertension, hypotension, tachycardia, bradycardia, arrhythmias, hyperventilation, hypoventilation, apnea, laryngospasm |
|
| Overdosage/Toxicology |
|
Symptoms of overdose include respiratory arrest, coma Supportive treatment |
|
| Stability |
|
Store at room temperature |
|
| Mechanism of Action |
|
Ultrashort-acting nonbarbiturate hypnotic used for the induction of anesthesia; chemically, it is a carboxylated imidazole and has been shown to produce a rapid induction of anesthesia with minimal cardiovascular and respiratory effects |
|
| Pharmacodynamics/Kinetics |
|
Distribution: Vd: 3.6 to 4.5 L/kg; rapid into body tissues; penetrates the central nervous system rapidly Protein binding: 76% Metabolism: Rapid in both liver and blood Half-life: Terminal: 2.6 hours |
|
| Usual Dosage |
|
Children >10 years and Adults: I.V.: 0.2-0.6 mg/kg over a period of 30-60 seconds for induction of anesthesia |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Nursing Implications |
|
Store in refrigerator |
|
| Dosage Forms |
|
Injection: 2 mg/mL (10 mL, 20 mL) |
|
|
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