No

Ophthalmic Agent, Antiglaucoma; Ophthalmic Agent, Miotic

Reverse toxic CNS effects caused by anticholinergic drugs; used as miotic in treatment of open-angle glaucoma; may be useful in specific case of narrow-angle glaucoma; accommodative esotropia

C

Hypersensitivity to echothiophate or any component; most cases of angle-closure glaucoma; active uveal inflammation or any inflammatory disease of the iris or ciliary body, glaucoma associated with iridocyclitis

Tolerance may develop after prolonged use; a rest period restores response to the drug

1% to 10%: Ocular: Stinging, burning eyes, myopia, visual blurring

<1%: Bradycardia, hypotension, flushing, nausea, vomiting, diarrhea, muscle weakness, retinal detachment, diaphoresis, browache, miosis, twitching eyelids, watering eyes, dyspnea

Symptoms of overdose include excessive salivation, urinary incontinence, dyspnea, diarrhea, profuse sweating

If systemic effects occur, administer parenteral atropine; for severe muscle weakness, pralidoxime may be used in addition to atropine

Increased toxicity: Carbamate or organophosphate insecticides and pesticides; succinylcholine; systemic acetylcholinesterases may increase neuromuscular effects

Store undiluted vials at room temperature (15°C to 30°C/59°F to 86°F); reconstituted solutions remain stable for 30 days at room temperature or 6 months when refrigerated

Produces miosis and changes in accommodation by inhibiting cholinesterase, thereby preventing the breakdown of acetylcholine; acetylcholine is, therefore, allowed to continuously stimulate the iris and ciliary muscles of the eye

Onset of action: Miosis: 10-30 minutes; Intraocular pressure decrease: 4-8 hours

Peak intraocular pressure decrease: 24 hours

Duration: Up to 1-4 weeks

Adults:

Accommodative esotropia:

Diagnosis: Instill 1 drop of 0.125% once daily into both eyes at bedtime for 2-3 weeks

Treatment: Use lowest concentration and frequency which gives satisfactory response, with a maximum dose of 0.125% once daily, although more intensive therapy may be used for short periods of time

None reported

None reported

No information available to require special precautions

No effects or complications reported

Be sure of solution expiration date; local irritation and headache may occur; notify physician if abdominal cramps, diarrhea, or salivation occurs; use caution if driving at night or performing hazardous tasks; do not touch dropper to eye; report any change in vision to physician

Keep refrigerated; do not touch dropper to eye

Powder for reconstitution, ophthalmic: 1.5 mg [0.03%] (5 mL); 3 mg [0.06%] (5 mL); 6.25 mg [0.125%] (5 mL); 12.5 mg [0.25%] (5 mL)