|
| U.S. Brand
Names |
|
| Ilopan-Choline® Oral; Ilopan®
Injection; Panthoderm® Cream
[OTC] |

|
|
| Generic
Available |
|
|
Yes |

|
|
| Synonyms |
|
|
Pantothenyl Alcohol |

|
|
| Pharmacological Index |
|
|
Gastrointestinal Agent, Stimulant |

|
|
| Use |
|
|
Prophylactic use to minimize paralytic ileus, treatment of postoperative
distention |

|
|
| Pregnancy Risk
Factor |
|
|
C |

|
|
| Contraindications |
|
|
Hemophilia; mechanical obstruction of ileus |

|
|
| Adverse
Reactions |
|
|
<1%:
Dermatologic: Dermatitis, urticaria
Gastrointestinal: Vomiting, diarrhea, hyperperistalsis
Hematologic: Prolonged bleeding time
Local: Irritation
Neuromuscular & skeletal: Paresthesia
Respiratory: Dyspnea |

|
|
| Drug
Interactions |
|
|
Increased/prolonged effect of succinylcholine (do not administer within 1
hour) |

|
|
| Mechanism of
Action |
|
|
A pantothenic acid B vitamin analog that is converted to coenzyme A
internally; coenzyme A is essential to normal fatty acid synthesis, amino acid
synthesis and acetylation of choline in the production of the neurotransmitter,
acetylcholine |

|
|
| Pharmacodynamics/Kinetics |
|
|
Absorption: Well absorbed |

|
|
| Usual Dosage |
|
|
Children and Adults: Relief of itching and aid in skin healing: Topical:
Apply to affected area 1-2 times/day
Adults:
Relief of gas retention: Oral: 2-3 tablets 3 times/day
Prevention of postoperative ileus: I.M.: 250-500 mg stat, repeat in 2 hours,
followed by doses every 6 hours until danger passes
Paralyzed ileus: I.M.: 500 mg stat, repeat in 2 hours, followed by doses
every 6 hours, if needed |

|
|
| Administration |
|
|
Not for direct I.V. administration; must be diluted |

|
|
| Mental Health: Effects
on Mental Status |
|
|
None reported |

|
|
| Mental Health:
Effects on Psychiatric
Treatment |
|
|
None reported |

|
|
| Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
|
No information available to require special precautions |

|
|
| Dental Health:
Effects on Dental Treatment |
|
|
No effects or complications reported |

|
|
| Nursing
Implications |
|
|
Not for direct I.V. administration |

|
|
| Dosage Forms |
|
|
Cream: 2% (30 g, 60 g)
Injection (Ilopan®): 250 mg/mL (2 mL, 10 mL, 30 mL)
Tablet (Ilopan-Choline®): 50 mg with choline bitartrate
25 mg |

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