No

Anticholinergic Agent, Ophthalmic

Diagnostic procedures requiring mydriasis and cycloplegia

C

Narrow-angle glaucoma, known hypersensitivity to drug

2% solution may result in psychotic reactions and behavioral disturbances in children, usually occurring approximately 30-45 minutes after instillation; use with caution in elderly patients and other patients who may be predisposed to increased intraocular pressure

1% to 10%:

Central nervous system: Restlessness, hallucinations, psychosis, hyperactivity, seizures, incoherent speech, ataxia

Dermatologic: Burning sensation

Ocular: Increase in intraocular pressure, loss of visual accommodation

Miscellaneous: Allergic reaction

Antidote, if needed, is pilocarpine

Decreased effect of carbachol, cholinesterase inhibitors

Store in tight containers

Prevents the muscle of the ciliary body and the sphincter muscle of the iris from responding to cholinergic stimulation, causing mydriasis and cycloplegia

Peak effect: Cycloplegia: 25-75 minutes; Mydriasis: 30-60 minutes

Duration: Recovery takes up to 24 hours

Ophthalmic:

Children: Instill 1 drop of 0.5%, 1%, or 2% in eye followed by 1 drop of 0.5% or 1% in 5 minutes, if necessary

Adults: Instill 1 drop of 1% followed by another drop in 5 minutes; 2% solution in heavily pigmented iris

To avoid excessive systemic absorption, finger pressure should be applied on the lacrimal sac during and for 1-2 minutes following application

No information available to require special precautions

No effects or complications reported

May cause blurred vision and increased sensitivity to light

Finger pressure should be applied to lacrimal sac for 1-2 minutes after instillation to decrease risk of absorption and systemic reactions

Solution, ophthalmic, as hydrochloride: 0.5% (2 mL, 5 mL, 15 mL); 1% (2 mL, 5 mL, 15 mL); 2% (2 mL, 5 mL, 15 mL)