| Generic Available |
|
Yes |
 |
| Synonyms |
| Probenecid and Colchicine |
|
| Pharmacological Index |
|
Antigout Agent |
|
| Use |
|
Treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout |
|
| Pregnancy Risk Factor |
|
C (oral); D (parenteral) |
|
| Adverse Reactions |
|
1% to 10%: Central nervous system: Headache, dizziness Dermatologic: Rash, alopecia Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, abdominal pain Hematologic: Anemia, leukopenia, aplastic anemia, agranulocytosis Hepatic: Hepatic necrosis, hepatotoxicity Neuromuscular & skeletal: Peripheral neuritis, myopathy Renal: Nephrotic syndrome, uric acid stones, polyuria Miscellaneous: Hypersensitivity reactions |
|
| Usual Dosage |
|
Adults: Oral: 1 tablet daily for 1 week, then 1 tablet twice daily thereafter |
|
| Administration |
|
Do not initiate therapy until acute attack has subsided |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding. |
|
| Nursing Implications |
|
Do not initiate therapy until an acute gouty attack has subsided |
|
| Dosage Forms |
|
Tablet: Colchicine 0.5 mg and probenecid 0.5 g |
|
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