|
| U.S. Brand
Names |
|
| Cloderm®
Topical |

|
|
| Generic
Available |
|
|
No |

|
|
| Synonyms |
|
|
Clocortolone Pivalate |

|
|
| Pharmacological Index |
|
|
Corticosteroid, Topical |

|
|
| Use |
|
|
Inflammation of corticosteroid-responsive dermatoses (medium potency topical
corticosteroid) |

|
|
| Pregnancy Risk
Factor |
|
|
C |

|
|
| Contraindications |
|
|
Known hypersensitivity to clocortolone; viral, fungal, or tubercular skin
lesions |

|
|
| Warnings/Precautions |
|
|
Adrenal suppression can occur if used for >14 days |

|
|
| Adverse
Reactions |
|
|
1% to 10%:
Dermatologic: Itching, erythema
Local: Burning, dryness, irritation, papular rashes
<1%: Hypertrichosis, acneiform eruptions, maceration of skin, skin
atrophy, striae, hypopigmentation, perioral dermatitis, miliaria
|

|
|
| Drug
Interactions |
|
|
No data reported |

|
|
| Mechanism of
Action |
|
|
Stimulates the synthesis of enzymes needed to decrease inflammation, suppress
mitotic activity, and cause vasoconstriction |

|
|
| Pharmacodynamics/Kinetics |
|
|
Absorption: Percutaneous absorption is variable and dependent upon many
factors including vehicle used, integrity of epidermis, dose, and use of
occlusive dressings;
Distribution: Small amounts enter systemic circulation mostly throughout skin
Metabolism: Remains to be defined (largely in liver)
Elimination: In urine and bile |

|
|
| Usual Dosage |
|
|
Adults: Apply sparingly and gently; rub into affected area from 1-4
times/day. Therapy should be discontinued when control is achieved; if no
improvement is seen, reassessment of diagnosis may be
necessary. |

|
|
| Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
|
No information available to require special precautions |

|
|
| Dental Health:
Effects on Dental Treatment |
|
|
No effects or complications reported |

|
|
| Patient
Information |
|
|
A thin film of cream or ointment is effective; do not overuse; do not use
tight-fitting diapers or plastic pants on children being treated in the diaper
area; use only as prescribed, and for no longer than the period prescribed;
apply sparingly in light film; rub in lightly; avoid contact with eyes; notify
physician if condition being treated persists or worsens |

|
|
| Nursing
Implications |
|
|
For external use only; do not use on open wounds; apply sparingly to
occlusive dressings; should not be used in the presence of open or weeping
lesions |

|
|
| Dosage Forms |
|
|
Cream, as pivalate: 0.1% (15 g, 45
g) |

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|
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