| U.S. Brand Names |
| Cormax® Ointment; Temovate® |
 |
| Generic Available |
|
Yes |
|
| Canadian Brand Names |
| Dermasone; Dermovate®; Gen-Clobetasol; Novo-Clobetasol |
|
| Synonyms |
| Clobetasol Propionate |
|
| Pharmacological Index |
|
Corticosteroid, Topical |
|
| Use |
|
Short-term relief of inflammation of moderate to severe corticosteroid-responsive dermatosis (very high potency topical corticosteroid) |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Known hypersensitivity to clobetasol; viral, fungal, or tubercular skin lesions |
|
| Warnings/Precautions |
|
Adrenal suppression can occur if used for >14 days. Topical foam is not for use in children <12 years of age. Topical foam should not be used with occlusive dressings unless directed by healthcare provider. |
|
| Adverse Reactions |
|
1% to 10%: Dermatologic: Itching, erythema, Local: Burning, dryness, irritation, papular rashes <1%: Hypertrichosis, acneiform eruptions, maceration of skin, skin atrophy, striae, hypopigmentation, perioral dermatitis, miliaria, eczema (foam), skin hypertrophy (foam) |
|
| Drug Interactions |
|
No data reported |
|
| Mechanism of Action |
|
Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Percutaneous absorption variable and dependent upon many factors including vehicle used, integrity of epidermis, dose, and use of occlusive dressings Metabolism: Remains to be defined Elimination: In urine and bile |
|
| Usual Dosage |
|
Adults: Topical: Foam: Scalp: Apply to affected scalp twice daily for up to 2 weeks ( less than or equal to 50 g/week) |
|
| Mental Health: Effects on Mental Status |
|
None reported |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
A thin film of cream or ointment is effective; do not overuse; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed and for no longer than the period prescribed; apply sparingly in light film; rub in lightly; avoid contact with eyes; notify physician if condition being treated persists or worsens; to apply foam, hold can upside down and apply directly to scalp; gently massage foam into affected area until foam disappears |
|
| Nursing Implications |
|
For external use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions; do not use occlusive dressings with foam unless directed by healthcare provider |
|
| Dosage Forms |
|
Cream, as propionate: 0.05% (15 g, 30 g, 45 g) Cream, as propionate, in emollient base: 0.05% (15 g, 30 g, 60 g) Gel, as propionate: 0.05% (15 g, 30 g, 45 g) Ointment, topical, as propionate: 0.05% (15 g, 30 g, 45 g) Scalp application, as propionate: 0.05% (25 mL, 50 mL) Foam (Olux™): 0.05% (100 g) |
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