| Generic Available |
|
No |
 |
| Synonyms |
| Butoconazole Nitrate |
|
| Pharmacological Index |
|
Antifungal Agent, Vaginal |
|
| Use |
|
Local treatment of vulvovaginal candidiasis |
|
| Pregnancy Risk Factor |
|
C (For use only in 2nd or 3rd trimester) |
|
| Contraindications |
|
Known hypersensitivity to butoconazole |
|
| Warnings/Precautions |
|
In pregnancy, use only during 2nd or 3rd trimesters; if irritation or sensitization occurs, discontinue use |
|
| Adverse Reactions |
|
1% to 10%: Genitourinary: Vulvar/vaginal burning <1%: Vulvar itching, soreness, edema, or discharge; polyuria |
|
| Drug Interactions |
|
No data reported |
|
| Stability |
|
Do not store at temperatures >40°C/104°F; avoid freezing |
|
| Mechanism of Action |
|
Increases cell membrane permeability in susceptible fungi ( Candida) |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Following intravaginal application small amounts of drug are absorbed systemically (25%) within 2-8 hours Half-life: 21-24 hours Elimination: Into urine and feces in approximate equal amounts |
|
| Usual Dosage |
|
Adults: Pregnant: Use only during 2nd or 3rd trimester |
|
| Mental Health: Effects on Mental Status |
|
None reported |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
May cause burning or stinging on application; if symptoms of vaginitis persist, contact physician |
|
| Nursing Implications |
|
May cause burning or stinging on application; if symptoms of vaginitis persist, contact physician |
|
| Dosage Forms |
|
Cream, vaginal, as nitrate: 2% with applicator (28 g) |
|
|
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