Yes

Antihistamine

Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria

C

Narrow-angle glaucoma; bladder neck obstruction; symptomatic prostatic hypertrophy; asthmatic attacks; stenosing peptic ulcer; hypersensitivity to brompheniramine or any component

>10%:

Central nervous system: Slight to moderate drowsiness (compared with other first generation antihistamines, brompheniramine is relatively nonsedating)

Respiratory: Thickening of bronchial secretions

1% to 10%:

Central nervous system: Headache, fatigue, nervousness, dizziness

Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal pain, xerostomia

Neuromuscular & skeletal: Arthralgia

Respiratory: Pharyngitis

Increased toxicity: CNS depressants, MAO inhibitors, alcohol, tricyclic antidepressants

Solutions may crystallize if stored below 0°C, crystals will dissolve when warmed

Competes with histamine for H₁-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract

Duration: Varies with formulation

Serum half-life: 12-34 hours

Time to peak serum concentration: Oral: Within 2-5 hours

Oral:

Children:

less than or equal to 6 years: 0.125 mg/kg/dose given every 6 hours; maximum: 6-8 mg/day

6-12 years: 2-4 mg every 6-8 hours; maximum: 12-16 mg/day

Adults: 4 mg every 4-6 hours or 8 mg of sustained release form every 8-12 hours or 12 mg of sustained release every 12 hours; maximum: 24 mg/day

Elderly: Initial: 4 mg once or twice daily. Note: Duration of action may be 36 hours or more, even when serum concentrations are low.

I.M., I.V., S.C.:

Children less than or equal to 12 years: 0.5 mg/kg/24 hours divided every 6-8 hours

Adults: 10 mg every 6-12 hours, maximum: 40 mg/24 hours

May be administered with food, milk, or water

Dilute in 1-10 mL D₅W or normal saline and infuse over several minutes; the patient should be in a recumbent position during the infusion

Sedation is common

Concurrent use with psychotropics may produce additive sedation

No information available to require special precautions

Chronic use of antihistamines will inhibit salivary flow, particularly in elderly patients; this may contribute to periodontal disease and oral discomfort

Avoid alcohol; take with food or milk; swallow whole, do not crush or chew extended release products; may cause drowsiness

Sustained release tablets should be swallowed whole, do not crush or chew

Elixir, as maleate: 2 mg/5 mL with 3% alcohol (120 mL, 480 mL, 4000 mL)

Injection, as maleate: 10 mg/mL (10 mL)

Tablet, as maleate: 4 mg, 8 mg, 12 mg

Tablet, sustained release, as maleate: 8 mg, 12 mg