Yes

Vitamin, Fat Soluble

Reduces severity of photosensitivity reactions in patients with erythropoietic protoporphyria (EPP)

C

Hypersensitivity to beta-carotene

Use with caution in patients with renal or hepatic impairment; not proven effective as a sunscreen

>10%: Dermatologic: Carotenodermia (yellowing of palms, hands, or soles of feet, and to a lesser extent the face)

<1%: Dizziness, bruising, diarrhea, arthralgia

Fulfills vitamin A requirements, do not prescribe additional vitamin A

The exact mechanism of action in erythropoietic protoporphyria has not as yet been elucidated; although patient must become carotenemic before effects are observed, there appears to be more than a simple internal light screen responsible for the drug's action. A protective effect was achieved when beta-carotene was added to blood samples. The concentrations of solutions used were similar to those achieved in treated patients. Topically applied beta-carotene is considerably less effective than systemic therapy.

Metabolism: Prior to absorption, converted to vitamin A in the wall of the small intestine and then further oxidized to retinoic acid and retinol in the presence of fat and bile acids; small amounts are then stored in the liver; retinol (active) is conjugated with glucuronic acid

Elimination: In urine and feces

Oral:

Adults: 30-300 mg/day

May be administered with meals

No information available to require special precautions

No effects or complications reported

Take exactly as directed; do not take more than the recommended dose. Take with meals. Skin may appear slightly yellow-orange. Not a proven sunblock. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Skin may appear slightly yellow-orange; not a proven sunscreen

Capsule: 15 mg, 30 mg