No

Anorexiant

Short-term adjunct in exogenous obesity

C-III

X

Known hypersensitivity or idiosyncrasy to sympathomimetic amines. Patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension (stage II or III), hyperthyroidism, glaucoma, agitated states, patients with a history of drug abuse, pregnancy, and during or within 14 days following MAO inhibitor therapy. Concurrent use with other anorectic agents; stimulant medications are contraindicated for use in children with attention deficit/hyperactivity disorders and concomitant Tourette's syndrome or tics.

>10%:

Cardiovascular: Arrhythmia

Central nervous system: False feeling of well being, nervousness, restlessness, insomnia

1% to 10%:

Cardiovascular: Hypertension,

Central nervous system: Mood or mental changes, dizziness, lightheadedness, headache, xerostomia

Endocrine & metabolic: Changes in libido

Gastrointestinal: Diarrhea, nausea, vomiting, stomach cramps, constipation, anorexia, weight loss

Ocular: Blurred vision

Miscellaneous: Increased diaphoresis

CYP3A3/4 enzyme substrate

Noncatechol sympathomimetic amines with pharmacologic actions similar to ephedrine; require breakdown by monoamine oxidase for inactivation; produce central nervous system and respiratory stimulation, a pressor response, mydriasis, bronchodilation, and contraction of the urinary sphincter; thought to have a direct effect on both alpha- and beta-receptor sites in the peripheral system, as well as release stores of norepinephrine in adrenergic nerve terminals; central nervous system action is thought to occur in the cerebral cortex and reticular-activating system; anorexigenic effect is probably secondary to the CNS-stimulating effect; the site of action is probably the hypothalamic feeding center

Adults: Oral: 25-50 mg 2-3 times/day, preferably twice daily (midmorning and midafternoon); maximum dose: 50 mg 3 times/day

Use with caution since amphetamines have actions similar to epinephrine and norepinephrine

No effects or complications reported

Take during day to avoid insomnia; do not discontinue abruptly, may be addicting with prolonged use

Monitor CNS

Tablet, as hydrochloride: 25 mg, 50 mg