No

Antibiotic, Penicillin

Treatment of susceptible bacterial infections involving the urinary tract, skin structure, upper and lower respiratory tract; activity is identical to that of ampicillin

B

Hypersensitivity to bacampicillin or any component or penicillins

Use with caution in patients allergic to cephalosporins; modify dosage in patients with renal impairment; high percentage of patients with infectious mononucleosis develop a rash during amoxicillin therapy

1% to 10%: Gastrointestinal: Gastric upset, diarrhea, nausea

<1%: Rash, pseudomembranous colitis, agranulocytosis, mildly increased AST, hypersensitivity reactions

Signs and symptoms: Neuromuscular sensitivity, many beta-lactam containing antibiotics have the potential to cause neuromuscular hyperirritability or convulsive seizures

Treatment: Hemodialysis may be helpful to aid in the removal of the drug from the blood, otherwise most treatment is supportive or symptom directed

Decreased effect of oral contraceptives

Increased levels with probenecid; allopurinol theoretically has has an additive potential for amoxicillin/ampicillin rash

Reconstituted suspension is stable for 10 days when stored in the refrigerator

Interferes with bacterial cell wall synthesis during active multiplication causing cell wall death and resultant bactericidal activity against susceptible bacteria

Protein binding: 15% to 25%

Metabolism: Hydrolyzed to ampicillin

Bioavailability: 80% to 98%

Half-life: 65 minutes, prolonged in patients with impaired renal function

Time to peak serum concentration: Area under the serum concentration time curve is 40% higher for bacampicillin than after equivalent ampicillin doses

Oral:

Children >25 kg and Adults: 400-800 mg every 12 hours

Dosing interval in renal impairment:

Cl_cr 10-30 mL/minute: Administer every 24 hours

Cl_cr <10 mL/minute: Administer every 36 hours

May be administered with meals or on an empty stomach; may mix with milk, formula, or juice

Renal, hepatic, and hematologic function tests

False-positive urine glucose with Clinitest®

Penicillins have been reported to cause apprehension, illusions, agitation, insomnia, depersonalization, and encephalopathy

May produce agranulocytosis; use caution with clozapine and carbamazepine

No information available to require special precautions

No effects or complications reported

Take oral suspension 1 hour before or 2 hours after a meal; report diarrhea promptly; entire course of medication (10-14 days) should be taken to ensure eradication of organism; should be taken in equal intervals around-the-clock to maintain adequate blood levels; may interfere with oral contraceptives, females should report symptoms of vaginitis

Assess patient at beginning and throughout therapy for infection; observe for signs and symptoms of anaphylaxis

Powder for oral suspension, as hydrochloride: 125 mg/5 mL [chemically equivalent to ampicillin 87.5 mg per 5 mL] (70 mL)

Tablet, as hydrochloride: 400 mg [chemically equivalent to ampicillin 280 mg]