No

Cholinergic Agonist; Ophthalmic Agent, Miotic

Produces complete miosis in cataract surgery, keratoplasty, iridectomy and other anterior segment surgery where rapid miosis is required

C

Acetylcholine is used primarily in the eye and there are no reports of its use in pregnancy; because it is ionized at physiologic pH, transplacental passage would not be expected

Hypersensitivity to acetylcholine chloride and any components; acute iritis and acute inflammatory disease of the anterior chamber

Systemic effects rarely occur but can cause problems for patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, GI spasm, urinary tract obstruction, and Parkinson's disease; open under aseptic conditions only

<1%: Bradycardia, hypotension, flushing, headache, altered distance vision, decreased night vision, transient lenticular opacities, dyspnea, diaphoresis

Treatment includes flushing eyes with water or normal saline and supportive measures; if accidentally ingested, induce emesis or perform gastric lavage

Decreased effect possible with flurbiprofen and suprofen, ophthalmic

Increased effect may be prolonged or enhanced in patients receiving tacrine

Prepare solution immediately before use and discard unused portion; acetylcholine solutions are unstable

Causes contraction of the sphincter muscles of the iris, resulting in miosis and contraction of the ciliary muscle, leading to accommodation spasm

Onset of miosis: Occurs promptly

Duration: ~10 minutes

Adults: Intraocular: 0.5-2 mL of 1% injection (5-20 mg) instilled into anterior chamber before or after securing one or more sutures

Reconstitute immediately before use

None reported

Intraocular product; should not impact psychiatric drug treatment

No information available to require special precautions

Ophthalmic use of acetylcholine has no effect on dental treatment

May sting on instillation; use caution while driving at night or performing hazardous tasks; do not touch dropper to eye

Discard any solution that is not used; open under aseptic conditions only

Powder, intraocular, as chloride: 1:100 [10 mg/mL] (2 mL, 15 mL)