|
| U.S. Brand Names |
| Isocom®; Isopap®; Midchlor®; Midrin®; Migratine® |
 |
| Generic Available |
|
Yes |
|
| Pharmacological Index |
|
Analgesic, Miscellaneous |
|
| Use |
|
Relief of migraine and tension headache |
|
| Pregnancy Risk Factor |
|
B |
|
| Contraindications |
|
Glaucoma; severe renal disease; hypertension; organic heart disease; hepatic disease; MAO inhibitor therapy |
|
| Adverse Reactions |
|
Central nervous system: Transient dizziness Dermatological: Rash |
|
| Usual Dosage |
|
Adults: Oral: 2 capsules at first sign of headache, followed by 1 capsule every 60 minutes until relieved, up to 5 capsules in a 12-hour period |
|
| Mental Health: Effects on Mental Status |
|
May cause drowsiness or dizziness |
|
| Mental Health: Effects on Psychiatric Treatment |
|
Contraindicated with MAOI |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Dosage Forms |
|
Capsule: Acetaminophen 325 mg, isometheptene mucate 65 mg, dichloralphenazone 100 mg |
|
| References |
|
Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301. Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43. Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511. |
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